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首页 > 招才引智 > 专家团队 > 医疗与生命科学领域 > PARK YONG DOO (朴龙斗)
PARK YONG DOO (朴龙斗)

PI,教授,问题性皮肤研究中心主任


教育背景
1992.3-1996.2   Chonnam National University(韩,全南国立大学)  本科生
1996.9-1997.8   北京语言文化大学  进修生
1997.9-2001.6   清华大学生物技术与工程系  研究生(硕博连读) 
2001.7-2001.12  哈佛大学医学院 CBBSM中心  博士后


工作履历
2018.5-         浙江清华长三角研究院问题性皮肤研究中心     主任
2006.5-         浙江清华长三角研究院生物技术与医药研究所  PI
2004.9-2016.8          (韩)成均馆大学医学院                      研究教授
2002.1-2007.3           三星集团生物医药研究中心                   首席研究员
2008.1-2011.1           南方医科大学                               特聘教授(兼职)


奖励与荣誉(市级及以上)
1)国家高端外国专家
2)浙江省“西湖友谊奖”
3)嘉兴市 “荣誉市民”
4)嘉兴市高层次外国专家
5)宁波市重点高层次人才
6)嘉兴市自然科学学术一等奖 (2012年)


发表论文、论著及专利
主要成果:
承担重要项目
1. 韩国2001健康研究与开发项目,韩国保健福祉部(01-PJ3-PG6-01GN12-0001)
2. 韩国21世纪健康研究与开发项目,韩国保健福祉部(03-PJ10-PG6-GN01-002)
3. 国家高端外国专家项目
4. 创新嘉兴精英引领计划高层次外国专家项目


代表性著作及论文

论文:
Atopic dermatitis research (特应性皮炎研究):
Yin SJ, Cho IH, Yang HS, Park YD*, Yang JM*. Analysis of the peptides detected in atopic dermatitis and various inflammatory diseases patients-derived sera. Int J Biol Macromol. 2018 Jan;106:1052-1061.
Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park*, Jun-Mo Yang*. Serum proteomic analyses for probing C3 fragment protein. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 981-988.
Shang-Jun Yin, Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park*, Jun-Mo Yang*. An integrated method for the detection of basic proteins in serum-derived proteomes. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 973-980.
Shang-Jun Yin, Daeui Park, Yue-Xiu Si, Hae Young Chung, Yong-Doo Park*, Jun-Mo Yang*.  An RNA interference based study for the role of ALDH1 in keratinocytes: DNA microarray, antibody–chip array and bioinformatics approaches. Process Biochemistry, Volume 49, Issue 10, October 2014, Pages 1612-1621.
Yin SJ, Si YX, Zhang M, Qian GY, Zhang F, Yan L, Lü ZR, Zhou HM, Yang HS, Park YD*, Yang JM*. Combination of free-flow electrophoresis and interactomics to analyze the dysregulated proteins of fibroblasts from atopic dermatitis patients. J Dermatol Sci. 2011 Feb;61(2):148-50.
Park YD*, Park D, Bhak J, Yang JM. Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. Proteomics Clin Appl. 2008 Mar;2(3):290-300.
Park YD, Lyou YJ, Yang JM. Two-dimensional electrophoresis analyses of atopic dermatitis and the chances to detect new candidate proteins by the variations in immobilized pH gradient strips. J Dermatol Sci. 2007 Jul;47(1):9-17. 
Park YD, Lyou YJ, Yang JM. Detection of down-regulated acetaldehyde dehydrogenase 1 in atopic dermatitis patients by two-dimensional electrophoresis. Exp Dermatol. 2007 Feb;16(2):130-4.
Park YD, Lyou YJ, Lee KJ, Lee DY, Yang JM. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Clin Exp Allergy. 2006 May;36(5):649-57.
Park YD, Jang HS, Kim SY, Ko SK, Lyou YJ, Lee DY, Paik YK, Yang JM. Two-dimensional electrophoretic profiling of atopic dermatitis in primary cultured keratinocytes from patients. Proteomics. 2006 Feb;6(4):1362-70.
Park YD, Kim SY, Jang HS, Seo EY, Namkung JH, Park HS, Cho SY, Paik YK, Yang JM. Towards a proteomic analysis of atopic dermatitis: a two-dimensional-polyacrylamide gel electrophoresis/mass spectrometric analysis of cultured patient-derived fibroblasts. Proteomics. 2004 Nov;4(11):3446-55.
Pigmentation research (皮肤黑色素研究):
Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study.
Wang ZJ, Zheng L, Yang JM, Kang Y, Park YD*. Int J Biol Macromol. 2018 Jun;112:667-674.
Shang-Jun Yin, Kun-Yuan Liu, Jinhyuk Lee, Jun-Mo Yang, Guo-Ying Qian, Yue-Xiu Si, Yong-Doo Park*. Effect of hydroxysafflor yellow A on tyrosinase: Integration of inhibition kinetics with computational simulation. Process Biochemistry, Volume 50, Issue 12, December 2015, Pages 2112-2120.
Wei Wang, Daeui Park, Sunyoung Ji, Shang-Jun Yin, Guo-Ying Qian, Hae Young Chung, Jun-Mo Yang, Jinhyuk Lee, Yong-Doo Park*. Computational prediction for the protein interactions of tyrosinase: Protein experimental interactome MAP. Process Biochemistry, Volume 48, Issue 4, April 2013, Pages 638-648.
Si YX, Wang ZJ, Park D, Chung HY, Wang SF, Yan L, Yang JM, Qian GY, Yin SJ, Park YD*. Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study. Int J Biol Macromol. 2012 Jan 1;50(1):257-62.
Yin SJ, Si YX, Wang ZJ, Wang SF, Oh S, Lee S, Sim SM, Yang JM, Qian GY, Lee J, Park YD*. The effect of thiobarbituric acid on tyrosinase: inhibition kinetics and computational simulation. J Biomol Struct Dyn. 2011 Dec;29(3):463-70.
Lü ZR, Seo E, Yan L, Yin SJ, Si YX, Qian GY, Park YD*, Yang JM. High-throughput integrated analyses for the tyrosinase-induced melanogenesis: microarray, proteomics and interactomics studies. J Biomol Struct Dyn. 2010 Oct;28(2):259-76.


部分授权专利、软件著作权及其他

专利(已授权)
1. 特应性皮炎角质细胞或血清衍生的生物标志物(10-1109043)
发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
2. 外源性特应性皮炎的生物标志物(10-1105811)
发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
3. 普遍特应性皮炎的生物标志物(10-1117799)
发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
4. 色素过多的生物标志物及其应用(10-1109739)
发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
5. 三氟乙醇用于酪氨酸酶活性调控(10-1123149)
发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)


其他

作为Lead Guest Editor在《Enzyme Research》杂志上出版了Special Issue:
Skin diseases-related enzymes: mechanisms and clinical applications.