PARK YONG DOO

教授

PI,教授,问题性皮肤研究中心主任

教育背景

  • 1992.03 - 1996.02   Chonnam National University(韩,全南国立大学),本科生
  • 1996.09 - 1997.08   北京语言文化大学,进修生
  • 1997.09 - 2001.06   清华大学生物技术与工程系,研究生(硕博连读)
  • 2001.07 - 2001.12   哈佛大学医学院CBBSM中心,博士后

工作履历

  • 2018.05 -       浙江清华长三角研究院问题性皮肤研究中心,主任
  • 2006.05 -       浙江清华长三角研究院生物技术与医药研究所,PI
  • 2004.09 - 2016.08   成均馆大学医学院(韩),研究教授
  • 2002.01 - 2007.03   三星集团生物医药研究中心,首席研究员
  • 2008.01 - 2011.01   南方医科大学,特聘教授(兼职)

奖励与荣誉(市级及以上)

  1. 国家高端外国专家
  2. 浙江省“西湖友谊奖”
  3. 嘉兴市 “荣誉市民”
  4. 嘉兴市高层次外国专家
  5. 宁波市重点高层次人才
  6. 嘉兴市自然科学学术一等奖 (2012年)

承担重要项目

  1. 韩国2001健康研究与开发项目,韩国保健福祉部(01-PJ3-PG6-01GN12-0001)
  2. 韩国21世纪健康研究与开发项目,韩国保健福祉部(03-PJ10-PG6-GN01-002)
  3. 国家高端外国专家项目
  4. 创新嘉兴精英引领计划高层次外国专家项目

代表性著作及论文

Atopic dermatitis research (特应性皮炎研究):

  1. Yin SJ, Cho IH, Yang HS, Park YD, Yang JM. Analysis of the peptides detected in atopic dermatitis and various inflammatory diseases patients-derived sera. Int J Biol Macromol. 2018 Jan;106:1052-1061.
  2. Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park, Jun-Mo Yang. Serum proteomic analyses for probing C3 fragment protein. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 981-988.
  3. Shang-Jun Yin, Hee Seung Yang, Ick-Hyun Cho, Qian Wang, Yong-Doo Park, Jun-Mo Yang. An integrated method for the detection of basic proteins in serum-derived proteomes. Process Biochemistry, Volume 51, Issue 8, August 2016, Pages 973-980.
  4. Shang-Jun Yin, Daeui Park, Yue-Xiu Si, Hae Young Chung, Yong-Doo Park, Jun-Mo Yang. An RNA interference based study for the role of ALDH1 in keratinocytes: DNA microarray, antibody–chip array and bioinformatics approaches. Process Biochemistry, Volume 49, Issue 10, October 2014, Pages 1612-1621.
  5. Yin SJ, Si YX, Zhang M, Qian GY, Zhang F, Yan L, Lü ZR, Zhou HM, Yang HS, Park YD, Yang JM. Combination of free-flow electrophoresis and interactomics to analyze the dysregulated proteins of fibroblasts from atopic dermatitis patients. J Dermatol Sci. 2011 Feb;61(2):148-50.
  6. Park YD*, Park D, Bhak J, Yang JM. Proteomic approaches to the analysis of atopic dermatitis and new insights from interactomics. Proteomics Clin Appl. 2008 Mar;2(3):290-300.
  7. Park YD, Lyou YJ, Yang JM. Two-dimensional electrophoresis analyses of atopic dermatitis and the chances to detect new candidate proteins by the variations in immobilized pH gradient strips. J Dermatol Sci. 2007 Jul;47(1):9-17.
  8. Park YD, Lyou YJ, Yang JM. Detection of down-regulated acetaldehyde dehydrogenase 1 in atopic dermatitis patients by two-dimensional electrophoresis. Exp Dermatol. 2007 Feb;16(2):130-4.
  9. Park YD, Lyou YJ, Lee KJ, Lee DY, Yang JM. Towards profiling the gene expression of fibroblasts from atopic dermatitis patients: human 8K complementary DNA microarray. Clin Exp Allergy. 2006 May;36(5):649-57.
  10. Park YD, Jang HS, Kim SY, Ko SK, Lyou YJ, Lee DY, Paik YK, Yang JM. Two-dimensional electrophoretic profiling of atopic dermatitis in primary cultured keratinocytes from patients. Proteomics. 2006 Feb;6(4):1362-70.
  11. Park YD, Kim SY, Jang HS, Seo EY, Namkung JH, Park HS, Cho SY, Paik YK, Yang JM. Towards a proteomic analysis of atopic dermatitis: a two-dimensional-polyacrylamide gel electrophoresis/mass spectrometric analysis of cultured patient-derived fibroblasts. Proteomics. 2004 Nov;4(11):3446-55.

Pigmentation research (皮肤黑色素研究):

  1. Proteomic analyses for profiling regulated proteins/enzymes by Fucus vesiculosus fucoidan in B16 melanoma cells: A combination of enzyme kinetics functional study.
  2. Wang ZJ, Zheng L, Yang JM, Kang Y, Park YD*. Int J Biol Macromol. 2018 Jun;112:667-674.
  3. Shang-Jun Yin, Kun-Yuan Liu, Jinhyuk Lee, Jun-Mo Yang, Guo-Ying Qian, Yue-Xiu Si, Yong-Doo Park*. Effect of hydroxysafflor yellow A on tyrosinase: Integration of inhibition kinetics with computational simulation. Process Biochemistry, Volume 50, Issue 12, December 2015, Pages 2112-2120.
  4. Wei Wang, Daeui Park, Sunyoung Ji, Shang-Jun Yin, Guo-Ying Qian, Hae Young Chung, Jun-Mo Yang, Jinhyuk Lee, Yong-Doo Park*. Computational prediction for the protein interactions of tyrosinase: Protein experimental interactome MAP. Process Biochemistry, Volume 48, Issue 4, April 2013, Pages 638-648.
  5. Si YX, Wang ZJ, Park D, Chung HY, Wang SF, Yan L, Yang JM, Qian GY, Yin SJ, Park YD*. Effect of hesperetin on tyrosinase: inhibition kinetics integrated computational simulation study. Int J Biol Macromol. 2012 Jan 1;50(1):257-62.
  6. Yin SJ, Si YX, Wang ZJ, Wang SF, Oh S, Lee S, Sim SM, Yang JM, Qian GY, Lee J, Park YD*. The effect of thiobarbituric acid on tyrosinase: inhibition kinetics and computational simulation. J Biomol Struct Dyn. 2011 Dec;29(3):463-70.
  7. Lü ZR, Seo E, Yan L, Yin SJ, Si YX, Qian GY, Park YD*, Yang JM. High-throughput integrated analyses for the tyrosinase-induced melanogenesis: microarray, proteomics and interactomics studies. J Biomol Struct Dyn. 2010 Oct;28(2):259-76.

部分授权专利、软件著作权及其他

  1. 特应性皮炎角质细胞或血清衍生的生物标志物(10-1109043)发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
  2. 外源性特应性皮炎的生物标志物(10-1105811)发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
  3. 普遍特应性皮炎的生物标志物(10-1117799)发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
  4. 色素过多的生物标志物及其应用(10-1109739)发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)
  5. 三氟乙醇用于酪氨酸酶活性调控(10-1123149)发明人:Yang Jun Mo(梁俊莫),Park Yong Doo(朴龙斗)

其他

作为Lead Guest Editor在《Enzyme Research》杂志上出版了Special Issue: Skin diseases-related enzymes: mechanisms and clinical applications.